Cuboid Syndrome is a disorder in the foot which is often badly recognised and frequently underdiagnosed. It's not very common, making up less than 5% of foot problems. In this condition the cuboid bone is presumed to become partly subluxed due to too much traction from peroneus longus tendon which passes under the bone. Whenever a foot is overpronated it is assumed that the cuboid isn't a stable as a pulley once the peroneus longus muscle contracts. As a result the lateral aspect of the cuboid bone is moved upwards and the medial aspect is pulled plantarly.

This is really an overuse type of injury, although the cuboid might also become subluxed as part of an immediate lateral ankle sprain.Clinically, there is outside foot pain on weightbearing, generally located over the calcaneocuboid joint and cuboid-metatarsal joints. This tends to present as vague outside foot pain. Pressing the cuboid bone upwards from below the foot can produce the symptoms and typically the range of motion is restricted compared to the other side. There have been no x-ray observations associated with cuboid syndrome. There are a number of other disorders that could imitate cuboid syndrome, for example sinus tarsi syndrome, a stress fracture and peroneal tendonitis. It is also considered a common symptom after plantar fascia surgical release for recalcitrant plantar fasciitis.

Dealing with Cuboid Syndrome starts off with activity changes, making sure that activity amounts are restricted to what can be tolerated. Ice may be used to help with the initial pain relief. Strapping to immobilize the area is another good first line strategy, commonly this is followed by foot supports to help support the cuboid bone. There is a distinct mobilization that is helpful in cuboid syndrome to deal with the subluxation, though there is some controversy surrounding this method as to precisely what the mobilization is doing.